Melanotan I
Afamelanotide
Melanocortin agonist for tanning and photoprotection.
Mechanism of Action
Stimulates melanocytes for melanin production.
Key Benefits
- Sunless tanning
- UV protection
Common Uses
What to Expect
Onset
Tanning becomes visible within 3–7 days; slower and more gradual than Melanotan II
Duration
Tan lasts weeks with maintenance dosing; more natural-looking and even than MT-II
What Users Report
- Gradual, natural-looking tan that develops evenly — often described as a 'beach tan' appearance
- Less nausea and fewer side effects compared to Melanotan II — better tolerated overall
- No significant libido effects, unlike Melanotan II — this is tanning-specific
- Darkening of existing moles and freckles (important to monitor throughout use)
- Slower onset than MT-II but the tan looks more natural and even
- Provides UV protection by increasing melanin — skin is more resistant to sunburn
- Preferred by users who want the tanning benefit without the sexual side effects of MT-II
- Approved in some regions (as Scenesse) for people with extreme sun sensitivity
Typical Timeline
Days 1–3: Melanocyte stimulation begins; no visible change yet. Days 3–7: First signs of tanning become visible, especially with some UV exposure. Days 7–14: Loading phase complete; desired tan level developing. Maintenance: 1–2 injections per week maintain the tan. Note: Always monitor moles and skin changes throughout use.
Side Effects
- Nausea, freckling, darkening of moles
Dosage Protocol
Loading: 0.25–1 mg daily subcutaneous until desired tan (5–10 days). Maintenance: 0.25–0.5 mg 1–2x/week. Research/wellness protocols only.
Always consult a physician before starting any peptide protocol.
Administration
Subcutaneous injection
FDA Status
FDA-approved for specific medical use (Scenesse); research otherwise
Stacks Well With
- Melanotan II (if libido desired)