Hexarelin
Hexarelin acetate
Potent ghrelin mimetic and one of the strongest growth hormone secretagogues.
Mechanism of Action
Strong GHSR agonist triggering powerful GH pulses (stronger than Ipamorelin).
Key Benefits
- Significant GH/IGF-1 elevation
- Muscle growth & recovery
- Possible cardioprotection
Common Uses
What to Expect
Onset
Strong GH pulse within 15–30 minutes of injection; body composition effects over weeks
Duration
GH pulse lasts 2–3 hours; full cycle benefits at 8–12 weeks; can desensitize over time
What Users Report
- A noticeable 'rush' or head tingling immediately after injection — a sign of the strong GH release
- Significantly improved sleep quality, especially with the bedtime dose
- Increased hunger (stronger than Ipamorelin but less than GHRP-6)
- Faster recovery between training sessions; muscles feel ready to train sooner
- Some water retention in the first weeks, which typically subsides
- Possible tingling, numbness, or a 'pins and needles' sensation after injection
- Considered the most potent GHRP in terms of raw GH release per dose
- Watch for desensitization — effects can diminish with prolonged continuous use, making cycling important
Typical Timeline
Minutes 15–30: GH release; head rush or tingling. Hours 1–3: Peak GH pulse. Weeks 2–4: Sleep and recovery improvements. Weeks 4–8: Body composition changes; muscle growth and recovery enhanced. Weeks 8–12: Peak cycle benefits. Important: Cycle off to prevent receptor desensitization.
Side Effects
- Increased hunger, mild cortisol/prolactin rise, flushing
Dosage Protocol
100–300 mcg per injection, 2–3 times daily via subcutaneous injection (on empty stomach). Beginner: 100 mcg 2x/day. Cycle: 8–12 weeks on, equal time off to prevent desensitization. Often stacked with GHRH analogs. Research protocols only.
Always consult a physician before starting any peptide protocol.
Administration
Subcutaneous injection
FDA Status
Category 2 (reclassification to Category 1 under discussion 2026 – physician supervised)
Stacks Well With
- CJC-1295
- Ipamorelin
Tags
Related peptides
CJC-1295 (with/without DAC)
Growth Hormone Releasing Hormone analog
Long-acting GH secretagogue.
Ipamorelin
Selective ghrelin mimetic – safest GH peptide.
Sermorelin
Shortest functional GHRH analog.
GHRP-2
Ghrelin mimetic GH releaser.